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The Thai Journal of Pharmaceutical Sciences

Abstract

Oral cancer is the sixth-largest kind globally of cancer and a major health issue in India as well and affects a large population that is very vulnerable to recurrences and a lower survival rate among all the other malignancies. Milk thistle is a phytochemical herb of interest that has been used as folk medicine since ancient times. Due to its potential benefits, the pharmaceutical industrial world is widely using silymarin (an active component of milk thistle) for commercial preparations. Knowing the quantity and identity of active components is of utmost importance. Therefore, robust, accurate, and precise analytical methods are needed to identify and quantify the active constituents of plants. This review comprises several studies of silymarin on oral cancer as well as critical information on liquid chromatographic techniques developed and used in pharmaceuticals and biological matrices for the assessment of silymarin/silybin. The critical chromatographic conditions such as column used, mobile phase composition, detection wavelength, flow rate, linearity, and retention time are discussed in this article. Furthermore, emphasized the gap in clinical and analytical perspectives to enable researchers to explore more on these thrust areas.

Publisher

Faculty of Pharmaceutical Sciences, Chulalongkorn University

First Page

361

Last Page

372

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Pharmacology Commons

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