Abstract
Background: About 99.0% of global population was living in the area where air pollutant levels exceed World Health Organization Standard. Particulate matter whose diameter is equal to or less than 2.5 microns (PM2.5), is an important risk factor for chronic diseases including chronic respiratory diseases, heart diseases and lung cancer. However, the association between PM2.5 and cerebrovascular event is still controversial, especially in Asian populations.
Objective: To assess the association between PM2.5 and hospital admissions due to stroke.
Methods: A retrospective study was conducted using air monitoring and health data during 2017 - 2019 in Hatyai, a business city in Thailand. The daily mean concentrations of PM2.5were obtained from the Thai Pollution Control Department. The daily numbers of hospital admissions due to stroke such as ischemic stroke, hemorrhagic stroke and all stroke were obtained from the Thai National Health Security Office Regional Office 12. The association between PM 2.5 and outcome were assessed using Zero-inflated Negative Binomial regression, applied with the lag time of 0 to 4. For sensitivity analysis, the subgroup analysis by age and sex was performed.
Results: The mean daily concentration of PM2.5 during the study period was 17.10 µg/m3 (4.00 - 74.10 µg/m3). Every 10 µg/ m3 increase in daily concentration of PM2.5 was associated with incidence rate ratio (95%CI) of hospital admissions due to hemorrhagic stroke of 1.26 (1.09 - 1.46), 1.27 (1.10 - 1.48) and 1.18 (1.02 - 1.38) at lag0, lag1 and lag2, respectively. No association was observed between the daily concentration of PM2.5 and ischemic stroke. According to sensitivity analysis, only positive association between PM2.5 and stroke were found in male sex subgroup at lag0.
Conclusion: Exposure to PM2.5 was associated with hemorrhagic stroke, a severe clinical condition. Therefore, health surveillance should also include monitoring the incidence of the hemorrhagic stroke, especially when the PM 2.5 exceeds standard limits.
DOI
10.56808/2673-060X.5447
Recommended Citation
Kasiravat, Piyanee
(2024)
"Effects of fine particulate matter on hospital admission due to stroke in a business city of Thailand,"
Chulalongkorn Medical Journal: Vol. 67:
Iss.
2, Article 8.
DOI: https://doi.org/10.56808/2673-060X.5447
Available at:
https://digital.car.chula.ac.th/clmjournal/vol67/iss2/8