The Thai Journal of Veterinary Medicine


Weanling Buffalo strain rats on a severe exposure to aflatoxin B1 (AFB1) in a dose of 20 ppm in the semisynthetic diet for 4 weeks revealed a marked degree of degeneration or/and hemorrhagic necrosis of liver, renal tubules, alveolar epithelium, heart muscles, gastrointestinal epithelium and testicles. It seemed that female rats of our experiment were equal or slightly more susceptible than the male rats. Hemosiderin-like granules were presented in Kupffer's cells, reticuloendothelial cells of spleen and peritubular area of kidney. These granules might probably represent insoluble aflatoxin complex deposition. However, at the end of week 32 after the severe exposure to AFB1 resulted in polycystic lesions with hyperplastic nodules in all lobes of liver.


Faculty of Veterinary Science, Chulalongkorn University

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