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The Thai Journal of Veterinary Medicine

Abstract

Anthelmintic resistance in gastrointestinal nematodes threatens sustainable goat production globally. While resistance is well-documented in many regions, data from Thailand remain limited. This study determined the prevalence of gastrointestinal nematodes and assessed the efficacy of albendazole and fenbendazole in meat goats in Maha Sarakham province, northeastern Thailand. A two-stage cross-sectional study was conducted on 10 meat goat farms between August 2021 and March 2022. In Stage 1, fecal samples from 150 goats were examined using simple flotation and sedimentation techniques to identify parasite morphology. In Stage 2, the McMaster technique was employed to quantify fecal egg counts (FEC). Twenty-six goats with FEC ≥150 EPG were allocated to receive albendazole (10 mg/kg, n = 11) or fenbendazole (15 mg/kg, n = 15). Fecal egg count reduction (FECR) was calculated on Day 14 following WAAVP guidelines. Resistance was defined as FECR <95%. Overall prevalence was 84.00% (95% CI: 77.30–89.01%), with Strongyle-type nematodes being most prevalent (77.33%, 95% CI: 70.00–83.30%), followed by Moniezia spp. (25.33%). Co-infections were observed in 22.0% of animals. Both drugs showed substantially reduced efficacy: albendazole FECR 71.95% (95% CI: 64.36–79.89%) and fenbendazole FECR 79.56% (95% CI: 68.58–89.78%), with no significant difference (P = 0.706). All 10 farms (100%) demonstrated resistance to both benzimidazoles. This study provides the first comprehensive evidence of widespread benzimidazole resistance in Thai goat populations. The universal resistance observed highlights an urgent need for integrated parasite management strategies, including pasture management, selective treatment protocols, and alternative control methods.

DOI

10.56808/2985-1130.3847

First Page

1

Last Page

10

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