Dynamics and evolution of genotype 1 porcine reproductive and respiratory syndrome virus following its introduction into a herd concurrently infected with genotypes 1 and 2

Authors

Thitima Tripipat
Kepalee Saeng-chuto
Adthakorn Madapong
Christopher James Stott
Angkana Tantituvanont
Pavita Kaewprommal
Jittima Piriyapongsa
Dachrit Nilubol

Abstract

This study was conducted to investigate the dynamics and evolution of porcine reproductive and respiratory syndrome virus (PRRSV) genotype 1 following its introduction into a herd concurrently infected with both PRRSV genotypes. The results demonstrated that 2 novel genotype 1 groups emerged, termed clusters II and III. The emergence of cluster II suggested that this cluster of genotype 1 virus potentially correlated with the outbreak. Then, cluster III was detected with the disappearance of cluster II. The evolution of the genotype 1 virus from cluster II to cluster III is likely to be associated with immune evasion induced by amino acid substitutions at N-linked glycosylation sites. In contrast, evolution of the genotype 2 isolates was not observed. This result suggests that genotype 2 viruses were not affected by the emergence of the genotype 1 virus and each genotype developed independently.

DOI

10.56808/2985-1130.3147

First Page

519

Last Page

529

Recommended Citation

Tripipat, Thitima; Saeng-chuto, Kepalee; Madapong, Adthakorn; Stott, Christopher James; Tantituvanont, Angkana; Kaewprommal, Pavita; Piriyapongsa, Jittima; and Nilubol, Dachrit (2021) "Dynamics and evolution of genotype 1 porcine reproductive and respiratory syndrome virus following its introduction into a herd concurrently infected with genotypes 1 and 2," The Thai Journal of Veterinary Medicine: Vol. 51: Iss. 3, Article 13.
DOI: https://doi.org/10.56808/2985-1130.3147
Available at: https://digital.car.chula.ac.th/tjvm/vol51/iss3/13