Streptococcus equi ssp. zooepidemicus (SEZ) is responsible for a wide variety of infections in many animal species. Studies aimed at developing safe and effective vaccines against SEZ infections are thus of great interest. SeseC_00396 was a novel protein identified in the previous study. In this study, recombinant SeseC_00396 of SEZ was expressed and showed a strong immunoreactivity with mini-pig convalescent sera. Studies in mice have revealed that the recombinant protein induced a marked antibody response which was associated with protection against SEZ infection. The hyperimmune sera against SeseC_00396 could efficiently kill the bacteria. In addition, it was also found that antiSeseC_00396 antibodies can significantly inhibit the formation of SEZ biofilm. Data from this study suggests that SeseC_00396 identified in SEZ may represent immunogens of interest for vaccine development.
Faculty of Veterinary Science, Chulalongkorn University
Yi, Li; Yang, Weiping; Li, Jinpeng; Wang, Shaohui; and Wang, Yang
"Identification and characterization of a novel protective antigen, SeseC_00396 of Streptococcus equi ssp. Zooepidemicus,"
The Thai Journal of Veterinary Medicine: Vol. 51:
2, Article 5.
Available at: https://digital.car.chula.ac.th/tjvm/vol51/iss2/5