Identification and characterization of a novel protective antigen, SeseC_00396 of Streptococcus equi ssp. Zooepidemicus

Authors

Li Yi
Weiping Yang
Jinpeng Li
Shaohui Wang
Yang Wang

Abstract

Streptococcus equi ssp. zooepidemicus (SEZ) is responsible for a wide variety of infections in many animal species. Studies aimed at developing safe and effective vaccines against SEZ infections are thus of great interest. SeseC_00396 was a novel protein identified in the previous study. In this study, recombinant SeseC_00396 of SEZ was expressed and showed a strong immunoreactivity with mini-pig convalescent sera. Studies in mice have revealed that the recombinant protein induced a marked antibody response which was associated with protection against SEZ infection. The hyperimmune sera against SeseC_00396 could efficiently kill the bacteria. In addition, it was also found that antiSeseC_00396 antibodies can significantly inhibit the formation of SEZ biofilm. Data from this study suggests that SeseC_00396 identified in SEZ may represent immunogens of interest for vaccine development.

DOI

10.56808/2985-1130.3114

First Page

231

Last Page

238

Recommended Citation

Yi, Li; Yang, Weiping; Li, Jinpeng; Wang, Shaohui; and Wang, Yang (2021) "Identification and characterization of a novel protective antigen, SeseC_00396 of Streptococcus equi ssp. Zooepidemicus," The Thai Journal of Veterinary Medicine: Vol. 51: Iss. 2, Article 5.
DOI: https://doi.org/10.56808/2985-1130.3114
Available at: https://digital.car.chula.ac.th/tjvm/vol51/iss2/5