The tripartite motif containing 62 (TRIM62) is a host antiviral factor. It was demonstrated in our previous study that chicken TRIM62 significantly inhibited the replication of reticuloendotheliosisvirus (REV). However, the effect of viral infection on the distribution of TRIM62 is still unknown. In the present study, we tested and evaluated the tissue distribution of TRIM62 and the REV infection correlativity. We found that the distribution and mRNA expression of TRIM62 were first increased and then decreased upon REV infection. The decrease of TRIM62 was mostly in the spleen. The results suggest REV inhibited the antiviral activity of TRIM62 by decreasing its expression.
Faculty of Veterinary Science, Chulalongkorn University
Yang, Jie; Li, Ling; Wang, Xiaoman; Cheng, Ziqiang; and Wang, Guihua
"Dynamic changes of TRIM62 distribution in REV infected chickens,"
The Thai Journal of Veterinary Medicine: Vol. 50:
4, Article 19.
Available at: https://digital.car.chula.ac.th/tjvm/vol50/iss4/19