The Thai Journal of Veterinary Medicine


The in vivo bone regenerative capacity and biocompatibility of bisphenol A glycidylmethacrylate (BisGMA) implants fabricated by Stereolithography Rapid Prototyping machine (SLA) wasinvestigated in rabbit’s calvarial defect model. The study focused on two different materials: BisGMA alone and hydroxyapatite (HA) incorporated BisGMA, of which were formulated especially for SLA fabrication. Each rabbit’s skull implant was fabricated with size 1x1 cm2according to the rabbit skull’s contour based on its Computed Tomographic dataand replaced at the full thickness cavarial defects in 6 rabbits. Computed Tomography (CT) scan and blood tests were performed at certain time points during 6 months after surgical operation to evaluate the bone regenerative capacity and biocompatibility. CT images revealedthat the newly formed bone was gradually increased according to the implantation periods and all rabbit skulls showed good healing response without adverse tissue reactions.There was no remarkable difference in bone regeneration compared between BisGMA and HAincorporated BisGMA.After 24 weeks, the implants with surrounding skull tissues were removed and observed for cellular response of boneto implants. Scanning electron microscope revealed more callus formation surrounding the BisGMA (3.870.05 mm) compared to HA incorporated BisGMA (3.210.22 mm, P= 0.023). From histological studies, BisGMA implants were encapsulated with thicker fibroustissue compared to HA incorporated BisGMA, suggesting that HA incorporated BisGMA induced less tissue reaction. Based on the present study in a rabbit calvarial defect model, it is concluded that SLA provides a well fitting implant. Furthermore, incorporation of HA to BisGMA improves biological compatibility with less fibrous tissue encapsulation.



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