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The Thai Journal of Veterinary Medicine

Abstract

The pharmacokinetic properties of enrofloxacin were investigated after a single intra-muscular (i.m.) and oral administration of 10 mg/kg b.w. to 12 healthy adult pigeons. Twelve pigeons were randomly divided to two groups. Blood samples were collected at different time points following drug administration. Plasma enrofloxacin concentrations were determined by reverse-phase high-performanceliquidchromatography. Pharmacokinetic analysis was conducted using non-compartmental methods via the ncappc package in R. The mean concentration area under curve (AUClast) for enrofloxacin was determined to be 21.75±5.67 μg·h/mL for i.m., administration and 17.30±4.94μg·h/mL for oral administration. The elimination half-life (T1/2λz) was 9.51±5.72 and 6.87±1.81 h for the i.m., and oral route, respectively. The mean maximum plasma concentration (Cmax) after i.m., administration was 2.50±0.27 μg/mL at 0.67±0.20 h, whereas after oral administration Cmaxwas 0.98±0.45μg/mL at 6.33±2.66 h. Mean residence time (MRTlast ) following i.m., injection was 11.02±2.28 and 14.85±1.78 h after oral administration. There are some discrepancies in part of the pharmacokinetics parameters of enrofloxacin between meat pigeons and other poultry.

First Page

261

Last Page

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