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The Thai Journal of Veterinary Medicine

Abstract

The pharmacokinetic properties of enrofloxacin were investigated after a single intra-muscular (i.m.) and oral administration of 10 mg/kg b.w. to 12 healthy adult pigeons. Twelve pigeons were randomly divided to two groups. Blood samples were collected at different time points following drug administration. Plasma enrofloxacin concentrations were determined by reverse-phase high-performanceliquidchromatography. Pharmacokinetic analysis was conducted using non-compartmental methods via the ncappc package in R. The mean concentration area under curve (AUClast) for enrofloxacin was determined to be 21.75±5.67 μg·h/mL for i.m., administration and 17.30±4.94μg·h/mL for oral administration. The elimination half-life (T1/2λz) was 9.51±5.72 and 6.87±1.81 h for the i.m., and oral route, respectively. The mean maximum plasma concentration (Cmax) after i.m., administration was 2.50±0.27 μg/mL at 0.67±0.20 h, whereas after oral administration Cmaxwas 0.98±0.45μg/mL at 6.33±2.66 h. Mean residence time (MRTlast ) following i.m., injection was 11.02±2.28 and 14.85±1.78 h after oral administration. There are some discrepancies in part of the pharmacokinetics parameters of enrofloxacin between meat pigeons and other poultry.

Publisher

Faculty of Veterinary Science, Chulalongkorn University

First Page

261

Last Page

264

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