The Thai Journal of Veterinary Medicine
Pharmacokinetics of enrofloxacin in meat pigeons after a single intramuscular and oral administration
The pharmacokinetic properties of enrofloxacin were investigated after a single intra-muscular (i.m.) and oral administration of 10 mg/kg b.w. to 12 healthy adult pigeons. Twelve pigeons were randomly divided to two groups. Blood samples were collected at different time points following drug administration. Plasma enrofloxacin concentrations were determined by reverse-phase high-performanceliquidchromatography. Pharmacokinetic analysis was conducted using non-compartmental methods via the ncappc package in R. The mean concentration area under curve (AUClast) for enrofloxacin was determined to be 21.75±5.67 μg·h/mL for i.m., administration and 17.30±4.94μg·h/mL for oral administration. The elimination half-life (T1/2λz) was 9.51±5.72 and 6.87±1.81 h for the i.m., and oral route, respectively. The mean maximum plasma concentration (Cmax) after i.m., administration was 2.50±0.27 μg/mL at 0.67±0.20 h, whereas after oral administration Cmaxwas 0.98±0.45μg/mL at 6.33±2.66 h. Mean residence time (MRTlast ) following i.m., injection was 11.02±2.28 and 14.85±1.78 h after oral administration. There are some discrepancies in part of the pharmacokinetics parameters of enrofloxacin between meat pigeons and other poultry.
Faculty of Veterinary Science, Chulalongkorn University
Wang, Xun; Shi, Fei; Gou, Yuhong; Jiang, Qiong; Gong, Jie; Tang, Huaqiao; Ye, Gang; Fang, Chen; Li, Yinlun; and Zhao, Ling
"Pharmacokinetics of enrofloxacin in meat pigeons after a single intramuscular and oral administration,"
The Thai Journal of Veterinary Medicine: Vol. 50:
2, Article 17.
Available at: https://digital.car.chula.ac.th/tjvm/vol50/iss2/17