Six dogs were diagnosed with pulmonary hypertension (PH) secondary to chronic degenerative mitral valve disease (CDMVD) on echocardiography. Imatinib (3 mg/kg, every 24 hours, PO) was initiated without any changes to the background therapy to treat the PH. Follow-up evaluations at 1, 3, 5 and 6 months revealed substantial clinical and hemodynamic improvements. One dog showed deterioration after the imatinib withdrawal to necessitate a restart therapy. No side effects were observed throughout the 6-month treatment course. Low-dose imatinib may provide a promising treatment alternative for CDMVD-associated PH in dogs.
Faculty of Veterinary Science, Chulalongkorn University
Leong, Zi Ping; Arita, Shinji; and Hikasa, Yoshiaki
"Long-term effect of low-dose imatinib therapy for pulmonary hypertension due to chronic degenerative mitral valve disease in six dogs,"
The Thai Journal of Veterinary Medicine: Vol. 48:
3, Article 21.
Available at: https://digital.car.chula.ac.th/tjvm/vol48/iss3/21