Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the important RNA viruses that affects swine production worldwide. To better improve vaccine efficacy, understanding the molecular mechanisms and viral-host interaction is important to increase the knowledge of vaccine response. The objective of this study was to investigate the expression levels of miR-29a and IFN-γ in pigs that received modified live PRRSV vaccine. The study revealed that both miR-29a and IFN-γ transcript levels increased in vivo early, at day 3 post vaccination, whereas levels of miR-29a and IFN-γ mRNA were not different at day 7 post vaccination. Our study is the first attempt to demonstrate the level of this miR-29a in response to PRRSV vaccination. However, the molecular mechanisms of miR-29a and its functional role during PRRSV infection require further investigation.
Nantakhruea, Sunaree; Aunjangwang, Nuntawan; Limsivilai, Orawan; and Surachetpong, Win
"Expression of miR-29a and IFN-γ in pigs vaccinated with modified live PRRS vaccine,"
The Thai Journal of Veterinary Medicine: Vol. 47:
2, Article 15.
Available at: https://digital.car.chula.ac.th/tjvm/vol47/iss2/15