Expression of miR-29a and IFN-γ in pigs vaccinated with modified live PRRS vaccine

Authors

Sunaree Nantakhruea
Nuntawan Aunjangwang
Orawan Limsivilai
Win Surachetpong

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the important RNA viruses that affects swine production worldwide. To better improve vaccine efficacy, understanding the molecular mechanisms and viral-host interaction is important to increase the knowledge of vaccine response. The objective of this study was to investigate the expression levels of miR-29a and IFN-γ in pigs that received modified live PRRSV vaccine. The study revealed that both miR-29a and IFN-γ transcript levels increased in vivo early, at day 3 post vaccination, whereas levels of miR-29a and IFN-γ mRNA were not different at day 7 post vaccination. Our study is the first attempt to demonstrate the level of this miR-29a in response to PRRSV vaccination. However, the molecular mechanisms of miR-29a and its functional role during PRRSV infection require further investigation.

DOI

10.56808/2985-1130.2832

First Page

273

Last Page

278

Recommended Citation

Nantakhruea, Sunaree; Aunjangwang, Nuntawan; Limsivilai, Orawan; and Surachetpong, Win (2017) "Expression of miR-29a and IFN-γ in pigs vaccinated with modified live PRRS vaccine," The Thai Journal of Veterinary Medicine: Vol. 47: Iss. 2, Article 15.
DOI: https://doi.org/10.56808/2985-1130.2832
Available at: https://digital.car.chula.ac.th/tjvm/vol47/iss2/15