The Thai Journal of Veterinary Medicine


The purpose of this study was to evaluate the protective efficacy of live LaSota strain Newcastle disease virus (NDV) vaccine administered with different routes against a NDV challenge in layer-type chickens. Fifty male layer-type chickens were divided into 3 groups. There were 20 chickens/group for the vaccinated groups (Groups 1 and 2) and 10 chickens for the non-vaccinated control group (Group 3). Chickens in Groups 1 and 2 received the vaccine individually at 4 weeks old by eye drop and oral drop, respectively. All chickens received NDV challenge individually by oral drop at 7 weeks old or 3 weeks post-vaccination (PV). At 3 weeks PV, the results reveal that the haemagglutination-inhibition (HI) titer of the vaccinated Group 1 was significantly higher than that of the vaccinated Group 2 (p<0.05) and they were significantly higher than that of the non-vaccinated Group 3 (p<0.05). The protection rate of the vaccinated Groups 1 and 2 were 100 and 60 percent, respectively. There was no protection in the non-vaccinated Group 3. The results of this study indicate that single vaccination with live LaSota strain NDV vaccine is adequate in protection against a NDV challenge in layer-type chickens if the chickens receive the appropriate route of vaccine administration.

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