Histopathological and Immunohistochemical Characterization of Spontaneous Uterine Leiomyomas in Two Captive Asian Elephants

Authors

Kidsadagon Pringproa
Hiroo Madarame
Jiraporn Sritun
Pitikarn Bumpenpol
Paninee Pedsri
Chalermchart Somgird
Chatchote Thitaram

Abstract

Two captive female Asian elephants (Elephas maximus) in Thailand were euthanatized after prolonged recumbency, weakness, and unresponsive treatment. Necropsy revealed multinodular masses of 5-10 cm in diameter which were irregular, large, white and firm in consistency scattered throughout the uterine horns and uteri of both the elephants. Histologically, the tumors displayed mildly pleomorphic, spindle-shaped cells arranged in interlacing pattern interpreted as muscle bundles. The bundles of the muscle cells were interspersed by small amounts of collagen fibers and blood vessels. For immunohistochemistry, the tumor cells showed diffuse positivity for vimentin, desmin, and smooth muscle actin. Based on the pathological results, uterine leiomyomas were diagnosed. This study describes the morphology and immunohistochemical characteristics of the uterine smooth muscle tumor in Asian elephants.

DOI

10.56808/2985-1130.2648

First Page

289

Last Page

294

Recommended Citation

Pringproa, Kidsadagon; Madarame, Hiroo; Sritun, Jiraporn; Bumpenpol, Pitikarn; Pedsri, Paninee; Somgird, Chalermchart; and Thitaram, Chatchote (2015) "Histopathological and Immunohistochemical Characterization of Spontaneous Uterine Leiomyomas in Two Captive Asian Elephants," The Thai Journal of Veterinary Medicine: Vol. 45: Iss. 2, Article 17.
DOI: https://doi.org/10.56808/2985-1130.2648
Available at: https://digital.car.chula.ac.th/tjvm/vol45/iss2/17