The Thai Journal of Veterinary Medicine


This study aimed to develop self-emulsifying drug delivery systems or self-microemulsifying drug delivery systems (SEDDS/SMEDDS) to thoroughly mix sweet basil oil and fingerroot oil in drinking water for chickens in order to utilize for coccidiosis prevention and treatment. Effects of surfactant and cosolvent type on the formulations were investigated. The selected formulations were then investigated for physical properties. In addition, the chemical stability of the formulations was studied by Gas Chromatography-Mass Spectrophotometry (GC-MS) after kept in three different conditions, i.e., 5±3 oC (in a refrigerator), 30±2 oC/75±5%RH, and 45±2 oC/75±5%RH, for four months. It was found that both sweet basil oil and fingerroot oil could be mixed with Tween80 to obtain clear yellowish liquids which further possibly formed into emulsions when diluted with water at appropriate concentrations. Both volatile oils provided small microemulsion regions when mixed with Tween80 and water. CremophorRH40 used as a surfactant had superior in mixing both volatile oils in SEDDS/SMEDDS formulations than Tween80 while polyethylene glycol 400 (PEG400) and propylene glycol (PG) showed similar efficacy as cosolvents. Finally, the SEDDS/SMEDDS formulations composed of CremophorRH40, PEG400 or PG, and sweet basil oil or fingerroot oil were successfully developed for homogeneously mixing in drinking water for chickens. All selected samples were clear liquid having spherical particles in nanometer-range (12.3-52.4 nm). The results also indicated that all samples were chemically stable when stored in well-closed containers at low temperature.

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