The Thai Journal of Veterinary Medicine
Abstract
Susceptibility to metronidazole and vancomycin, drugs of choice for Clostridium difficile infection, of 15 C. difficile isolates from 6 healthy Asian elephants was determined. All of the isolates belonged to only 1 ribotype pattern and carried both toxin A and B genes. The Minimal inhibitory concentration range of metronidazole and vancomycin, drugs of choice for treatment of C. difficile infection, was 0.125-4.0 μg/ml and 0.125-2.0 μg/ml, respectively. Moreover, MIC50 and MIC90 for metronidazole were 0.75 and 1.5 μg/ml while vancomycin was 1.0 and 2.0 μg/ml. There was no evidence of resistance to these antimicrobials. These results might be a preliminary data for further study of animal C. difficile.
DOI
10.56808/2985-1130.2484
First Page
313
Last Page
316
Recommended Citation
Sthitmatee, Nattawooti; Warinrak, Thanya; and Wongkalasin, Waroot
(2013)
"Susceptibility of Clostridium difficile Isolated from Healthy Captive Asian Elephants to Metronidazole and Vancomycin,"
The Thai Journal of Veterinary Medicine: Vol. 43:
Iss.
2, Article 22.
DOI: https://doi.org/10.56808/2985-1130.2484
Available at:
https://digital.car.chula.ac.th/tjvm/vol43/iss2/22