The Thai Journal of Veterinary Medicine


The clinical outcome of PCSO-524 application in the treatment of canine osteoarthritis and spinal disorderwas studied at the Small Animal Teaching Hospital, Chulalongkorn University. Eighty-four dogs were included inour study. Thirty-one dogs showed signs of osteoarthritis (OA) in both hip joints and shoulder joints; 33 dogs had OAin stifle joints from cranial cruciate ligament rupture; and 20 dogs had neurological signs of the cauda equinasyndrome. All affected dogs were treated by 50 mg/ 10 kg of PCSO-524, PO for twelve weeks. Neurological grading,lameness scores and neurological examinations were evaluated before and after the administration of PCSO-524 fortwo and four weeks. Radiographic examinations were taken before and after the administration of PCSO-524 for fourweeks. The results revealed that a large percentage of dogs experienced improvements in clinical lameness and ownerpreference although only a few dogs had better radiographic findings. Some of the dogs showed worse radiographicfindings, whereas the clinical signs improved. Although the percentages of the improved clinical lameness betweenthe two OA patient groups were high, but were not statistically and significantly different, the radiographic OAfindings improved more in patients that had OA in the hip and shoulder joints than in patients that had OA in thestifle joints.



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