The Thai Journal of Veterinary Medicine


Noni (Morinda citrifolia L.) has long been used to treat various conditions in folklore medicine. Presently,most studies focus on antioxidant and anti-cancer activities while it is also claimed by noni juice-consumers toproduce happiness. Mood disorders, e.g. anxiety, are symptoms that reflected the disorder of neurotransmitters, oneof the most prominent is the monoaminergic system. Anxiety affects people throughout the world; people have beenseeking medicine for treatment while natural products may also alleviate this unfavorable symptom. The presentstudy examined whether noni contained anxiolytic-like effect when tested with elevated plus-maze (EPM), a standardtest for anxiety, and whether this effect was related to change in monoamine transmitters in brain. Male Wistar ratswere fed either noni juice or water (1 ml/day, PO for 15 days), and the anxiety level was measured with EPM. Thebrain monoamines were then analyzed with HPLC-electrochemical detector. We found that the noni-treated ratsspent more time in the opened-arm than the control rats, indicating that the noni-treated rats were less anxious thanthe control rats. The neurochemical analysis revealed significant changes in noradrenergic, dopaminergic orserotonergic systems in amygdala, hippocampus and substantia nigra of the noni-treated group. These findingsindicated that the noni juice produced anxiolytic-like behaviors in rats partially by modulating neurochemicalmetabolisms in brain regions related to anxiety.



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