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The Thai Journal of Veterinary Medicine

Abstract

Porcine circovirus type 2 (PCV2) was first recognized as a causative agent of post weaning multisystemicsyndrome or PMWS in Canada in 1991. Subsequently, it has been reported in almost all intensive pig productioncountries, and currently all associated diseases linked to PCV2 are included under the term porcine circovirusassociated diseases or PCVAD. PCV2 can be divided into 2 major genotypes referred to genotype 1 (PCV2b) andgenotype 2 (PCV2a). In Thailand, PMWS was first reported in 1998. However, only one isolate of Thai PCV2 from ourgroup has been submitted to GenBank (AY864814). Therefore, the objective of this study was to determine thegenetic characterizations of 12 ORF2 of PCV2 isolates from Thai pigs with PCVAD during 2007-2010. Twelve ThaiPCV2 sequences were analyzed together with 19 representative ORF2 sequences. Interestingly, all 12 recent ThaiPCV2 sequences belong to genotype 1 consisting of subgroup 1A/B (10/12, 83.33%) and 1C (2/12, 16.67%). Insummary, based on genetic characterization and phylogenetic analysis, a few specific substitution patterns wereobserved in amino acid positions and genotype 1, subgroup 1A/B was predominated in Thai pigs with PCVAD inthis study. More samples are needed to investigate the existence of genotype 2.

First Page

163

Last Page

170

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