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The Thai Journal of Veterinary Medicine

Abstract

Anticoagulant rodenticide, especially coumarin derivative, is the most common cause of companion animalintoxication. Retrospective pathological examination was performed on 10 dogs suspected to be intoxicated withanticoagulant rodenticides. Coumarin derivatives, cause of intoxication, were confirmed by toxicologicalidentification using thin layer chromatography technique and spectral analysis. Macroscopically and microscopically,all cases showed generalized hemorrhages in various organs. Microscopic examination of hemorrhagic scores of liver,kidneys, intestines, heart, and lungs were 2.28+1.94, 2±2, 1±1.63, 0.8±1.68, and 1.1+2.32, respectively. Highesthemorrhagic score of the liver indicated that it suffered the most hemorrhagic effects related to anticoagulantrodenticides. The important factors might be high blood supply, function of metabolization and vitamin K1dependent coagulation factor producing of the liver. Kidney also had high hemorrhagic score due to its high bloodsupply and function of elimination. In summary, this retrospective study revealed pathological findings ofhemorrhagic lesions in dogs with coumarin intoxication. The histological assessment of hemorrhagic lesion in thisstudy was evaluated and score in systematic way.

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