In order to understand the change of MMP-2 and MMP-9 in dogs with mammary gland tumor (MGT), theactivity of MMP-2 and MMP-9 in plasma samples, MGT tissues and near by normal mammary gland tissues wereevaluated by gelatin zymography. The levels of MMP-2 and MMP-9 were significantly higher in tumor tissues thanthose in normal gland tissues (p<0.05). Plasma MMP-9 levels in malignant cases were higher than those in benign(p=0.15) and non-tumor cases (p<0.05). Likewise, plasma MMP-2 levels in malignant MGT cases were higher thannon-tumor (p<0.01) and benign cases (p=0.54). Furthermore, plasma MMP-9 levels were reflected and positivelycorrelated with MMP-9 in tumor tissues (r=0.78, p=0.02), but not MMP-2. Our results indicated that the MMP-2 andMMP-9 levels are associated with tumor malignancy, and plasma MMP-9 activity can become a potential marker bothin follow-up and prognosis of canine MGT patients.
Faculty of Veterinary Science, Chulalongkorn University
Shia, Wei-Yau; Liu, Shih-Ming; Lee, Chun-Sheng; Lin, Jian-Liang; Chou, Chih-Chung; Yuasa, Yumi; Chang, Shih-Chieh; and Lee, Wei-Ming
"The Activity of Plasma Matrix Metalloproteinase-9 as a Marker to Reflect the Tissue Level of Mammary Glands Tumor in Dogs,"
The Thai Journal of Veterinary Medicine: Vol. 41:
1, Article 3.
Available at: https://digital.car.chula.ac.th/tjvm/vol41/iss1/3