The Thai Journal of Veterinary Medicine


Puppies antibody titer response to Canine Distemper virus (CDV) before and after vaccination with a CDV-combined vaccine was studied using a serum neutralization test (SN). A total of 201 samples were obtained from puppies at the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University. The result showed that 100%(82/82) of the puppies, before vaccination, had no detectable SN titre (CDV SN-titer <2). Puppies 14 days after the first and second vaccination had a log2 (geometric mean titer, GMT) of 5.2 and 7.8. A group of 20 puppies in which the antibody response was followed after vaccination for a period of time showed the comparable results (log2 [GMT] = 5.3 and 8.5, respectively). There was no difference in the CDV SN-titers among puppies of different ages at vaccination, nor those with a vaccination history for their mothers (p>0.05).



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