The Thai Journal of Veterinary Medicine


The efficacy of Ivomec-F was evaluated in 60 cattle and 14 buffaloes that had a naturally acquired infection of Fasciola gigantica. Some animals were also concurrently infected with gastrointestinal nematodes. The animals were divided equally into treatment and control groups. Treatment group 1 which consisted of 30 cattle, were administered a single subcutaneous dose of Ivomec-F (1% ivermectin /10% clorsulon) 1 ml/ 50 kg body weight. Control group 2 which consisted of 30 untreated cattle, were given the same volume of physiological saline. Groups 3 and 4 (7 treated and 7 control buffaloes) were treated in a similar manner as the cattle. Fourteen days after treatment, 5 animals from each group of cattle and 3 animals from each group of buffalo were slaughtered and examined for parasites in the bile ducts, gall bladder, liver parenchyma and the gastrointestinal tract. Fecal and blood samples were collected from all animals on day 0, before treatment began and during weeks 2, 4, 8, 12, 16, 20 and 24 after treatment. Fecal samples were examined for Fasciola eggs per gram (epg) using the beads technique. Gastrointestinal nematode eggs and infective larvae were looked for by brine floatation and fecal cultivation, respectively. Standard hematological tests (total rbc, total wbc, Hb, Ht, MCV, MCH and MCHC) were carried out and selected biochemical parameters (total protein, albumin, iron, creatinine, BUN, GGT, AST and ALT) were measured. The results showed that there were no living flukes in the bile ducts, gall bladder and liver parenchyma and no nematodes in the gut of the treated groups of slaughtered animals. A few liver fluke eggs were found in the bile of 2 treated cattle and one buffalo. Neither liver fluke eggs nor gastrointestinal nematodes were found in the feces of treated animals from weeks 2 to 16 after treatment. This study clearly showed that Ivomec -F was highly effective against mature F. gigantica and gastrointestinal nematodes in both cattle and buffaloes. In addition, Ivomec-F did not affect any hematological or biochemical parameters that were measured.


Faculty of Veterinary Science, Chulalongkorn University

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