The Thai Journal of Veterinary Medicine


This experiment was conducted to study the effects of antidiarrheal drugs on kidney and urinary bladder functions of twelve adult male mongrel dogs. Animals were divided into three groups of four dogs each and given Clioquinol 600 mg (groups I), Phanquinone 60 mg (group II), and Phanquinone 60 mg + Clioquinol 600 mg (group III) once daily for 3 days. The study on kidney functions revealed that there were no significant changes in urine flow (V), glomerular filtration rate (GFR), renal plasma flow (RPF), and renal blood flow (RBF) as compared with premedicated period in all groups. Animals were given the drugs containing Phanquinone showed signs of urinary frequency and haematuria. Postmortem examination did not reveal any pathological changes in the cortex and medulla of kidneys, ureters and urethra. The gross pathological lesions showed of signs edematous, swelling, and haemorrhage of urinary bladder. Histopathological changes of urinary bladder revealed sloughing of epithelial mucosa, submucosal haemorrhage, submucosal edema, intermuscular edema, and muscular degeneration. These results indicated that Phanquinone was the main factor causing pathological lesion in urinary bladder. This effect was probably concomitant with acidity of urine in the bladder.

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