Journal of Metals, Materials and Minerals
Publication Date
2026
Abstract
This study investigates the influence of transition metal (Fe, Co, Mn) doping on the surface properties and in-vitro bioactivity of TiO2 nanowires. It aims to elucidate how transition-metal doping alters the surface behavior and biological response of TiO2 nanowires, enabling their potential use in biocompatible and magnetically responsive materials. Magnetic TiO2 nanowires doped with transition metals (Mx+/TiO2) were successfully prepared by a hydrothermal method using titanium dioxide in alkaline solution. Cations were added with Ti/Mx+ molar ratios of 5 to produce Fe/TNW, Co/TNW, and Mn/TNW. Characterization using SEM and XRD determine their surface properties. In-vitro bioactivity tests were conducted by observing the response of C2C12 cells. A cytotoxicity assay determined the effect of TiO2 Nanowires (5 mg∙mL‒1) on C2C12 cell viability at 48 h and 72 h. The results showed that metal-doped TiO2 nanowires did not significantly affect cell activity, and C2C12 cell differentiation remained. In conclusion, transition metal-doped TiO2 nanowires do not affect C2C12 cell activity at certain doses. The magnetic properties of doped TiO2 nanowires open new opportunities for controlled drug delivery using external magnets.
DOI
10.55713/jmmm.v36i1.2527
First Page
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Last Page
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Recommended Citation
Misriyani, Misriyani; Enayah, Enayah; Tian, Z. Ryan; and Ilhamjaya, Andi Meutiah
(2026)
"Surface properties and in-vitro bioactivity studies of TiO2 nanowire doped transition metal (M=Fe, Co, and Mn),"
Journal of Metals, Materials and Minerals: Vol. 36:
No.
1, Article 17.
DOI: 10.55713/jmmm.v36i1.2527
Available at:
https://digital.car.chula.ac.th/jmmm/vol36/iss1/17