pH-responsive polymeric nanostructures for cancer theranostics

Authors

• Devadass Jessy Mercy
• Karthick Harini
• Swaminathan Madhumitha
• Chinnadurai Anitha
• Jayakumar Iswariya
• Koyeli Girigoswami
• Agnishwar Girigoswami

Publication Date

2023

Abstract

Responsive polymeric nanostructures are being designed to improve the efficiency of existing treatment techniques by delivering therapeutics in precise locations. The properties of the particles can be altered to act as a probe for imaging applications also. Hence, an effective theranostic agent can be tailor-made to meet the requirements. The pH variability has aroused considerable interest in nano-responsive-stimulus production since the mild acidic condition is a hallmark of the tumor microenvironment. The cargo sealed inside the carrier will be released either by swelling or disassembly of the carrier as they meet a pH drop. The modification strategy for the synthesis of pH-responsive polymers is discussed in the manuscript. Fabrication of pH-responsive theranostic agents can conquer major limitations of conventional treatment techniques. Herein we reported imperative insights on recent pH-sensitive polymeric nanomaterials for the treatment of various disease conditions, especially cancer.

DOI

10.55713/jmmm.v33i2.1609

First Page

1

Last Page

15

Recommended Citation

Jessy Mercy, Devadass; Harini, Karthick; Madhumitha, Swaminathan; Anitha, Chinnadurai; Iswariya, Jayakumar; Girigoswami, Koyeli; and Girigoswami, Agnishwar (2023) "pH-responsive polymeric nanostructures for cancer theranostics," Journal of Metals, Materials and Minerals: Vol. 33: No. 2, Article 1.
DOI: 10.55713/jmmm.v33i2.1609
Available at: https://digital.car.chula.ac.th/jmmm/vol33/iss2/1