Journal of Metals, Materials and Minerals

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Shellac wax is a waste product from shellac manufacturing process and has not been reported to be used as pharmaceutical matrix base. This study was to prepared and characterized shellac wax - poloxamer 407 matrix tablet comprising hydrophilic or hydrophobic drug which were prepared by molten technique. The ratios of poloxamer 407: shellac wax was varied and subsequently loaded with the different drug content before characterized with differential scaning calorimetry (DSC), thermogravimetric analysis (TGA) and powder x-ray diffractometry (PXRD). Drug release study was also performed for 25 mg drug loaded matrix tablet in distilled water using dissolution apparatus II at 50 rpm, 37°C. Dissolution data were then fitted with five mathematic release equations by least square method to determine drug release kinetic. DSC and PXRD showed the solid dispersion for low content of hydrophobic drug in poloxamer 407. TGA showed no drug and other compound degraded during preparation. Drug release and drug release kinetic was dependent on content of poloxamer 407 and hydrophilicity of the model drug. Therefore shellac waxpoloxamer based could be used as matrix component for developing the controlled drug delivery systems in form of matrix tablet fabricated with mold technique.

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