An accidental discovery of ductal adenocarcinoma of the pancreas in an adult horse with severe abdominal pain

Authors

Thita Wonghanchao, Graduate School, Kasetsart University, Kampeang Sean Campus, Nakorn Pathom 73140, ThailandFollow
Kanokpan Sanigavatee, Graduate School, Kasetsart University, Kampeang Sean Campus, Nakorn Pathom 73140, ThailandFollow
Chanoknun Poochipakorn, Graduate School, Kasetsart University, Kampeang Sean Campus, Nakorn Pathom 73140, ThailandFollow
Onjira Huangsaksri, Graduate School, Kasetsart University, Kampeang Sean Campus, Nakorn Pathom 73140, ThailandFollow
Phudit Maneesaay, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, ThailandFollow
Rungrueang Yodsheewan, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, ThailandFollow
Metha Chanda, Faculty of Veterinary Medicine, Kasetsart UniversityFollow

Abstract

A native pony, eight years old and male, was tentatively diagnosed with abdominal pain and treated immediately. Sequential hematological profiles revealed increased levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatinine, as well as reduced albumin. After the pony's death, which occurred eight days after treatment began, a necropsy was performed. The liver's external surface showed small foci, but no gross lesion was observed in the pancreas, which was enlarged. Haematoxylin and eosin (H&E) staining of the liver showed multifocal inflammation in the hepatic parenchyma, coinciding with bile duct hyperplasia. The pancreas H&E staining showed well-differentiated tubular glands with normal pancreatic islet morphology. The pancreatic immunohistochemical staining was positive for pan-cytokeratin in the cytoplasm, except in the pancreatic islet cells. It also confirmed negative chymotrypsin staining of the pancreatic tissue, indicating simple and branching ductal structures instead of acinar cells. The pancreas's histopathology was consistent with ductal adenocarcinoma, a condition previously unreported in adult equids. This result suggests that pancreatic tumors should be considered an uncommon differential diagnosis for abdominal pain in adult equids.

DOI

10.56808/2985-1130.3655

First Page

109

Last Page

114

Recommended Citation

Wonghanchao, Thita; Sanigavatee, Kanokpan; Poochipakorn, Chanoknun; Huangsaksri, Onjira; Maneesaay, Phudit; Yodsheewan, Rungrueang; and Chanda, Metha (2024) "An accidental discovery of ductal adenocarcinoma of the pancreas in an adult horse with severe abdominal pain," The Thai Journal of Veterinary Medicine: Vol. 54: Iss. 1, Article 15.
DOI: https://doi.org/10.56808/2985-1130.3655
Available at: https://digital.car.chula.ac.th/tjvm/vol54/iss1/15