Canine babesiosis is a serious disease that is accompanied by the development of shock. The aim of the work was to establish shock, assess its degree, as well as to conduct a clinical trial of anti-shock infusion therapy. 100 dogs of different breeds, weighing 20–40 kg, aged 2–4 years, were involved. The studies used oscillometry (blood pressure, pulse rate), assessment of vascular-platelet hemostasis (platelet count, spontaneous aggregation ability), coagulogram (prothromine and activated partial thromboplastin time, fibrinogen), enzyme immunoassay (fibrin degradation products and D-dimer), biochemical (soluble fibrin-monomer complexes) and hemodynamic (circulating blood volume, hematocrit) methods of investigation. In dogs with acute babesiosis sub-compensated shock grade II developed. The basis for the diagnosis is a significant decrease in the specific volume of circulating blood (p<0.001) and average blood pressure (p<0.05), an increase in the Allgöwer’s Shock Index (p<0.05). Disseminated intravascular coagulation develops at the stage of consumption coagulopathy, which is confirmed by an increase in the level of soluble fibrin-monomer complexes (p<0.001), fibrin degradation products and D-dimer (p<0.05), hypofibrinogenemia (p<0.001), multidirectional shifts in activated partial thromboplastin time and prothrombin time tests. This condition is urgent and requires anti-shock therapy. Infusion therapy with a mixture of solutions of the plasma substitute Rheopolyglucine and the disaggregant Persantine at a dose of 5 ml (45 mg Dexrtan and 2.5 mg Dipyridamole) per 1 kg of animal body weight restores researching parameters and indicators for 48 hours. The use of drugs in an infusion mixture is more effective than using them separately.
Faculty of Veterinary Science, Chulalongkorn University
Dubova, Oksana; Kovalova, Lyudmila; Dubovyi, Anatolyi; Kovalov, Pavel; and Chala, Inna
"Shock status and anti-shock infusion therapy in canine acute spontaneous babesiosis,"
The Thai Journal of Veterinary Medicine: Vol. 52:
1, Article 13.
Available at: https://digital.car.chula.ac.th/tjvm/vol52/iss1/13