The Thai Journal of Veterinary Medicine


The aims of this study were to determine the relationship between tear osmolarity (TO), Schirmer tear test-1 (STT- 1) and tear film break-up time (TBUT) values in canines and to determine the impact of eye drops containing gintonin - a ginseng-derived lysophosphatidic acid (LPA) receptor ligand - on these indices. Fourteen canines (four English springer spaniels and ten Labrador retrievers) were randomized into two groups: the control group received only placebo eye drops (carboxymethylcellulose), while the experimental group received carboxymethylcellulose eye drops containing 5 µg of gintonin. Treatment was applied twice per day for a period of four weeks and STT-1, TBUT and TO were evaluated both prior to and following the treatment period; the latter using I-PEN® VET (I-MED Animal Health, QC, Canada). Pearson's correlation coefficients were calculated to investigate potential associations between baseline TO, STT-1 and TBUT values. Within-group statistical significance of value changes induced by treatment was determined using Student’s t-test. Positive correlations exist between TO and STT-1 values, as well as between TO and TBUT values (P = 0.001 and P = 0.032, respectively). Gintonin treatment significantly increased only TBUT (21.0 ± 11.2 s versus 7.5 ± 2.8 s) and TO (317.1 ± 18.1 mOsm/L versus 302.2 ± 19.3 mOsm/L) values (P < 0.01 and P < 0.05, respectively). The results suggest that gintonin improves canine tear film quality, as indicated by increased TBUT and TO values.

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