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The Thai Journal of Veterinary Medicine

Abstract

In this study, the possible protective effect of red radish containing total phenolic content and antioxidant components on histopathological and immuno histochemical active caspase-3, TNF-α and Iba-1, serum ALT activity, triglyceride, total cholesterol, LDL-cholesterol, liver malondialdehyde (MDA) and nitric oxide (NO) levels were evaluated in CCl4induced liver injury in Wistar rats. The rats were randomly divided into six groups (n= 12 to each group). The first group was used as a control which was given only intraperitoneal 0.9% NaCl (0.2 mL / kg / bw); while fermented red radish (FRR) at a dose of 250 mg/kg or 500 mg/kg was given daily by intragastricadministration to group II and group III, respectively for seven consecutive days. Carbon tetrachloride (CCl4) diluted 1:1 ratio in corn oil and was given (1.5 mL/kg) tothe rats in group IV by intraperitoneal injection. Group V and VI received FRR at a dose of 250 mg/kg or 500 mg/kg, respectively for seven consecutive days prior to CCl4injection. Pretreatment with FRR at 250 mg/kg and 500 mg/kg followed by CCl4exposure had no ameliorative effect on the histopathological changes in the liver. It is thought that FRR application has a partial antioxidative effect by decreasing the biochemical and lipid peroxidation levels in the control group but this is not effective in the treatment of damage to liver tissue. In conclusion, it has been concluded that newinvestigations should be done to determine the healing effects of red radish on fermented tissues using different doses to give the best results without any side effects.

Publisher

Faculty of Veterinary Science, Chulalongkorn University

First Page

405

Last Page

416

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