A hyperdynamic circulatory state is a common consequence of portal vein hypertension. Interestingly, this case report demonstrates acute canine leptospirosis manifesting with abdominal effusion, which it is focused ona hyperdynamic circulatory state, caused by portal hypertension. Severe acute kidney injury caused by leptospirosis in this case was hypothesized to be aggravated by renal hypoperfusion. This condition was noticed to occur in a similar way to hepatorenal syndrome (HRS) in humans. Briefly, a dog with leptospirosis manifesting with abdominal effusion which was diagnosed to be the consequence of hyperdynamic circulatory state caused by hepatopathy and severe acute kidney injury. Peritoneal dialysis was done in the anuric state resulting in a decrease in blood urea nitrogen (BUN) and serum creatinine. However, it was insufficient to improve short-term survival. Regarding the treatment of HRS in humans,vasopressin analogues and alpha-adrenergic agonists have been used for the treatment of HRS and have been seen to reduce mortality. However, the outcome of these drugs for a complicated hyperdynamic circulatory state treatment in dogs remains to be studied further in a large population.
Fungbun, Numfa; Kampa, Naruepon; Jitpean, Supranee; and Boonbal, Nitaya
"Hyperdynamic circulatory state in a dog with leptospirosis: a case report,"
The Thai Journal of Veterinary Medicine: Vol. 50:
2, Article 19.
Available at: https://digital.car.chula.ac.th/tjvm/vol50/iss2/19