Hyarulonicacid (HA) is an abundant molecule found in synovial fluid and plays an important role as a lubricant and shock absorber for the joints. Nonetheless, the effects of synovial fluid replacement with HA after canine stifle surgery remains elusive. A retrospective study was conducted on 54 small breed dogs with either medial patellar luxation (MPL) or cranial cruciate ligament ruptures (CCLR). Dogs were classified as HA (21 with MPL-HA and 16 with CCLR-HA) or control (10 with MPL-C and 7 with CCLR-C) groups. The weight bearing score, lameness score, and pain scores were compared between HA and control groups on 1, 3, 7, 14 and 28 days post-operation. Interestingly, the weight bearing scores at 1 and 7 days post-operation were significantly different between MPL-C and MPL-HA (D1: 4.0±0.0 vs 3.2±0.1, P-value <0.01; D7: 2.8±0.2 vs 2.3±0.1, P-value = 0.038) and between CCLR-C and CCLR-HA (D1: 4.0±0.0 vs 3.7±0.1,P-value = 0.02; D7: 3.2±0.2 vs 2.3±0.1, P-value = 0.02). The lameness score on D28 was significantly different between MPL-C (1.00.2) and MPL-HA (0.50.1; P-value = 0.045) (Figure 2). However, there was no difference in lameness scores between CCLR-C and CCLR-HA on any assessed day. Pain on palpation was not different between control and HA-treated groups. The present study suggests that synovial fluid replacement with an intra-articular HA injection provides beneficial effects in dogs that have undergone stifle surgery for correction of MPL and CCLR. Optimal frequency of HA administration warrants further study.
Faculty of Veterinary Science, Chulalongkorn University
Trairatthanom, Jiradet; Trairatthanom, Sasithorn; and Thengchaisri, Naris
"A retrospective study of the effect of single dose intra-articular hyaluronic acid injection on postoperative recovery in dogs undergoing stifle surgery,"
The Thai Journal of Veterinary Medicine: Vol. 49:
4, Article 2.
Available at: https://digital.car.chula.ac.th/tjvm/vol49/iss4/2