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The Thai Journal of Veterinary Medicine

Abstract

The current study was conducted to evaluate the effects of sub-therapeutic antibiotics (avilamycin and flavophospholipol) in animal feed on anti-oxidative and anti-inflammatory properties in broilers to understand the mechanisms of AGPs. Four hundred and fifty six 1-day-old broilers (ROSS 308) were divided into 3 groups with 4 replications. Three experimental diets composed of a corn-soybean meal based diet supplemented with 0, 10 mg/kg avilamycin and 5 mg/kg flavophospholipol were randomly provided to the broilers for 42 days, respectively. Results showed that the AGPs significantly decreased TBA-MDA adduct in serum as well as villi tissue of the broilers, especially flavophospholipol. However, flavophospholipol and avilamycin significantly increased IFN-γ and TNF-α concentration in the serum of broilers. TGF-β was not affected by the AGPs supplementation. These results indicated that the anti-oxidative and immune modulatory properties of AGPs could be an indirect mechanism to promote animal health and production.

Publisher

Faculty of Veterinary Science, Chulalongkorn University

First Page

89

Last Page

95

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