The Thai Journal of Veterinary Medicine


Ethanolic extracts from fruit pericarp of mangosteen (Garcinia mangostana L.) possess many biological andpharmacological activities. However, chronic toxicity study of ethanolic extract has never been investigated. Theobjective of this study was to evaluate the safety of 95% ethanolic extract from mangosteen pericarp in animal model.The oral administration of the extract was performed in 180 Wistar rats randomly allocated to six groups, each of15/sex. Group 1 was control group receiving distilled water. Group 2 to 6 were treatment groups receiving the extractat the doses of 10, 100, 500, 1000 and 1000 mg/kg/day for six months respectively. The last group was assigned to bethe satellite group for the study of reversibility of the extract effects after two-week of extract withdrawal. The resultsrevealed that the highest dose extract produced significantly lower body weights in both male and female rats,compared to their corresponding control groups. The extract at any tested doses did not affect the animals’ behavior,health status and nor did produce any abnormality of clinical manifestations and hematological values. Clinicalchemistry results showed that the male rats treated with 500 mg/kg/day extract onward had significantly higherALT than their control group. Both male and female receiving the highest dose extract had significantly higher AST,whereas their glucose levels were significantly lower when compared to their corresponding control groups. Themale rats of the highest dose and satellite groups had significantly higher BUN values than their control group. Thefemale rats receiving the extract at the dose of 500 mg/kg/day onward had significantly higher BUN and creatininevalues than their control group. Histopathological results of visceral organs revealed no significant lesion related tothe extract; except the satellite group of both sexes, which had significantly higher lesion of centrilobular hydropicdegeneration in their livers than the corresponding control groups. Such alteration may be caused by the highest dosemangosteen pericarp extract. In conclusion, the high dose mangosteen pericarp extract affected liver and kidney.Safety of chemical constituents in the extract should be further investigated before the usage for health promotion.

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