The Thai Journal of Veterinary Medicine


A9-year-old female Shih Tzu dog was presented with a 3-day history of anorexia, depression, vomiting, and watery diarrhea. The clinical symptoms progressed continuously until the dog died, 3 days after admission. At necropsy numerous white nodules of various sizes were found in the small intestine, particularly the ileum. Microscopically, the mass revealed diffused, infiltrative growth of a well-differentiated adenocarcinoma invading the submucosa and muscular layers of the small intestinal wall. The mass was characterized by an acinar or tubular pattern with mucin in the lumen. The tumor cells were atypical cuboidal pleomorphic columnar epithelial cells with hyperchromatic round medium-sized nuclei and prominent nucleoli which were amphophilic to basophilic cytoplasmic staining. An intense fibrous tissue reaction in the serosa and omentum was associated with metastatic tumors in the surrounding mesentery. Metastases were also found in the lung and the urinary bladder being transported via the lymphatic vessels. Immunohistochemically, the tumor cells stained intensely with cytokeratin, but not with vimentin. Based on histopathology and immunohistochemistry, the tumor was identified as a small intestinal adenocarcinoma.

First Page


Last Page