The Thai Journal of Veterinary Medicine


According to Lardy et al. (1964) the key enzymes of gluco-neogenesis are pyruvate carboxylase, phosphoenolpyruvate carboxykinase (EC 4.1.132) and L-alanine 2-oxoglutarate amino transferase (EC The activity of these enzymes may be controlling factors in the rate of formation of glucose from amino acid. These key enzymes of gluconeogenesis are founded exclusively in the liver and kidney and significant amounts are not found in other tissues (Exton 1967), Ross (1967), Nishiitsutsuji (1964). The mechanism by which hormonal and dietary effect is expressed on enzyme activity and the rate of gluconeogenesis is obscure, but no definitive evidence supports the theoretical proposal that hormone stimulation of gluconeogenesis is a result of induction or repression of protein synthesis (Weber et al. 1964, 1965, 1966).

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