The Thai Journal of Veterinary Medicine


Thirteen groups of cattle in five provinces of Thailand were tested serologically for their response to Foot-and-mouth disease virus type ◊ vaccine. The animals were tested before and after immunisation by the ELISA procedure. The proportion of animal with significant titers of antibody before immunisation was 64 percent (range 19 - 95 percent}, while proportion with antibody after immunisation was 86 percent (range 42 - 100 percent). Prevaccination antibody had an effect on the response of the animal to immunisation, while some cattle apparently fully susceptible animals failed to respond to the vaccine. Further study on ways to overcome the effect of pre-existing specific antibody and on the reasons why some animals did not respond seem necessary.

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