The Thai Journal of Veterinary Medicine


Intravenous administration of Russell's viper venom (0.1 mg/kg b.w.) resulted in marked changes in general circulation and renal hemodynamics in 7 anaesthetized male mongrel dogs. During initial postinjection period, mean arterial blood pressure, pulse pressure and heart rate showed to decrease significantly, thereafter it returned to the control level in a short period of 2 h after injection. Cardiac output decreased while packed cell volume significantly increased after venom injection. Renal plasma flow, renal blood flow, glomerular filtration rate, renal fraction and the rate of urine flow decreased over the period of 2 h after venom injection. Total peripheral resistance significantly increased as compared with the control. After venom injection, the renal fraction (% cardiac output) was reduced while the ratio of renal vascular resistance and total peripheral resistance was markedly increased. These findings suggest that an intrarenal mechanism seem to be responsible for the reduction of renal blood flow and filtration rate in the second hour after venom injection.

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