The Thai Journal of Pharmaceutical Sciences


The properties of modified starch derived from Pennisetum glaucum (PT) seed as a suspending agent in metronidazole benzoate suspension was evaluated. Matured PT seeds were steeped for 72h, wet milled and the slurry washed with water through a muslin cloth to obtain native PT starch (NPS) which was dried at 60°C. NPS slurry was heated (70°C), cooled (40°C), and submerged in 3.5%w/v sodium hypochlorite for 10 min, washed with 95%v/v alcohol till neutral to litmus. The modified starch (MPS) was dried (50°C), classified (180μm). NPS and MPS were characterized using standard methods. Metronidazole benzoate (MTBZ) suspensions were formulated using 2.5%w/v, 5.0%w/v and 7.5%w/v of MPS as suspending agent. Similar concentrations of acacia and methylcellulose were used as standard. An MTBZ suspension without polymer served as control. The suspensions were evaluated for pH, sedimentation, flow rate, viscosity and re-dispersibility within 28 days. Results show that modification enhanced the densities, compressibility, hydration capacity and swelling index of MPS. The suspensions had stable pH and viscosities. Sedimentation volume increased with increase in concentration of polymer(MPS>Methylcellulose>acacia>control) while flow rate decreased with increased polymer concentrations. The MTBZ suspensions were re-dispersed on agitation. MPS formed more stable suspensions than acacia and methylcellulose at similar concentrations.


Faculty of Pharmaceutical Sciences, Chulalongkorn University

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