A new series of 1,3,4-oxadiazole derivatives (3a-j) were synthesized by reacting p-toluic benzhydrazide (1) and substituted aromatic aldehydes (2) in the presence of ceric ammonium nitrate as catalyst and dichloromethane as a solvent medium. The structures of the new compounds were assigned based on IR, 1H-NMR, and mass spectral data and further evaluated for their in vitro anti-inflammatory potential using various protein denaturation methods following bovine serum and egg albumin assay. Some tested compounds 3e, 3f, and 3i displayed moderate anti-inflammatory activity compared to the standard diclofenac sodium.
Faculty of Pharmaceutical Sciences, Chulalongkorn University
Gatphoh, Banylla Felicity Dkhar; Aggarwal, Natasha Naval; Kumar, Hemanth; and Revanasiddappa, B. C.
"Anti-inflammatory activity of new 1,3,4-oxadiazole derivatives,"
The Thai Journal of Pharmaceutical Sciences: Vol. 45:
6, Article 8.
Available at: https://digital.car.chula.ac.th/tjps/vol45/iss6/8