The Thai Journal of Pharmaceutical Sciences


Background: This study investigated the psychometric properties of the Thai Short Form-12 Health Survey (SF-12v2) and reported SF-12v2 scale scores based on the general Thai population’s age and gender. Methods: Multistage sampling was used to recruit 1200 general Thai participants. For all SF-12v2 scales, item description, ceiling/floor effects, convergent validity for item-scale and SF-12v2 and EQ-5D correlations, known-group validity, exploratory factor analysis (EFA), test-retest reliability, and responsiveness were studied. Results: Ceiling effect was observed for all scales (5.8–72.6%). Floor effect was detected for all scales except for social functioning, role emotion, and mental health. Item-scale correlation coefficients ranged from 0.65 to 1.00. Moderate correlations between SF-12v2 and EQ-5D were observed. EFA yielded a two-factor structure accounting for 64% of the total variance. Scale scores were lower among female, older, and poorly educated individuals and those with lower incomes and chronic diseases. Test- retest reliability demonstrated fair-to-good reproducibility for all scales (Intraclass correlation coefficients: 0.49–0.64). Moreover, the SF-12v2 was more sensitive to health deterioration than to health improvement. Conclusion: These preliminary results confirmed that the Thai SF-12v2 is valid and reliable. Therefore, the Thai SF-12v2 is an appropriate health-related quality of life instrument for the Thai population.


Faculty of Pharmaceutical Sciences, Chulalongkorn University

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