Introduction: Although Sesbania grandiflora Linn. roots have valuable pharmacological effects, the comprehensive awareness about its toxicity potential has been lacking. Objectives: The objectives of the study were to assess the acute oral toxicity of methanolic fraction of S. grandiflora root (MFSGR). Materials and Methods: The female albino mice were divided into two groups (n = 5), one group served as normal control while the other treated with MFSGR (2000 mg/kg, p.o). Both the groups of mice were observed for 14 days for various parameters according to the Organization for Economic Cooperative and Development guidelines 425 TG. Results: Oral administration of MFSGR at a dose of 2000 mg/kg did not result in mortality and treatment-related adverse reactions such as variation in water and food consumption, alteration in body weight, relative organ weights, hematological and biochemical parameters. However, treatment showed mild changes in behavioral patterns such as sleeping and itching during initial time point. Further, histopathological evaluation of vital organs exhibited normal architecture and this observation provided good support to general and biochemical measurements. Conclusion: The present study revealed that the MFSGR did not show any signs of toxicity in female albino mice. Hence, the methanolic fraction can be used for the pharmacological studies by calculating dose based on toxicity studies.
Faculty of Pharmaceutical Sciences, Chulalongkorn University
Vinay, N. S.; Babitha, S.; Nandeesh, R.; Paramesh, S.; Manjunath, E.; Geetha, J. P.; Veerapur, V. P.; Swetha, B.; and Prasanth, H. V. Keerthi
"Evaluation of acute oral toxicity of
methanolic fractions of Sesbania grandiflora Linn. roots in albino mice,"
The Thai Journal of Pharmaceutical Sciences: Vol. 45:
2, Article 2.
Available at: https://digital.car.chula.ac.th/tjps/vol45/iss2/2