The Thai Journal of Pharmaceutical Sciences


Introduction: The aim of this work is to formulate and study the thermoresponsive system with hyaluronic acid (HA) as a polysaccharide backbone grafted with poly-(N-isopropylacrylamide) (pNIPAM) for stabilization of highly sensitive molecule. Methods: The nanogel forming polymer was synthesized through EDC/NHS coupling reaction. The HA grafted pNIPAM (HA-g-pNIPAM) can be self-assembled to form gel particle. The synthesized HA-g-pNIPAM polymers were characterized by 1H NMR. Size, influence of media to forming nanogel, thermoresponsive behavior and influence of HA-g-pNIPAM nanogel network on curcumin loading capacity and stability were investigated by dynamic light scattering (DLS) and UV-VIS spectrophotometry. Result and Discussion: The results showed that the nanogel prepared in ultrapure water is appropriate to form nanogel with submicron-size range. The lower critical solution temperature (LCST) of HA-g-pNIPAM nanogels appeared at 33°C. This study also indicated the importance of polymer network as solubility and stability enhancer of curcumin which could be a model for other labile molecules or insoluble drugs.


Faculty of Pharmaceutical Sciences, Chulalongkorn University

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