Chulalongkorn University Dental Journal

Publication Date



Objective To identify single nucleotide polymorphisms (SNPs) that associated with different occlusal relationship in a group of Thai population. Materials and Methods One hundred and sixty unrelated Thai subjects†who participated†in Ramathibodi GWAS study for thyrotoxic hypokalemic periodic paralysis (TTPP) (Jongjaroenprasert, 2012) were selected. The subjects that were 20 years old and above with at least a pair of untilted permanent first molars or canines were selected from these subjects. Seventeen subjects met these criteria in our study.† Angleûs/canine classification of subjects were observed† both intraorally and from diagnostic models. Eight hundred and sixty four† human active SNPs from 28 related genes were selected from previous craniofacial studies. PERL software with Fisher exact test was used to identify the SNPs that correlated with subjectsû occlusal relationship.† Results There were 17 SNPs† from 6 genes including IGF1, HSPG2, MATN1, TGFB2, VEGF and EVC† that significantly correlated with Angleûs/canine class I occlusal relationship and† 27 SNPs from† 5 genes including IGF1, HSPG2, MATN1, TGFB1 and LTBP2 that significantly correlated with Angleûs/canine class III occlusal relationship†(P value < 0.05). These findings show that there are specific SNPs in the marker genes that correlated with Angleûs/canine class l and class III occlusal relationship. Conclusion There are significant correlations between SNPs and occlusal relationship in a Thai population subgroup. This finding leads to a†further understanding in genetic †basis of occlusal relationship.



First Page


Last Page


Included in

Dentistry Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.