Chulalongkorn University Dental Journal

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An ideal treatment outcome of pulpal exposure during restorative procedures is to regain the primary structure of tubular dentin as well as maintain the vitality and healthiness of the dental pulp. Presumably this gold standard result requires pulp capping materials with antibacterial, anti-inflammatory, and dentin-pulp tissue regenerative properties. Various capping materials have been used in dentistry but none have been able to predictably induce the regeneration of underlying tubular dentin. Recently, potentially applicable tissue engineering strategies using scaffolds containing growth factors were introduced with promising results for dentin regeneration in animals, and similar approaches have been shown to be successful in non-dental clinical problems such as bone regeneration. This article presents a review of dental pulp responses to commercially available pulp capping materials and discusses candidate bioactive molecules investigated in animals for dentin-pulp regeneration.



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