Chulalongkorn University Dental Journal

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This article presents proliferative verrucous leukoplakia (PVL), a distinct form of oral leukoplakia which exhibits aggressive behavior due to its high rates of recurrence and malignant transformation. It is a disease of unknown origin. The prevalence and distribution of this lesion are different from those of other forms of oral leukoplakia, and its clinical-pathologic appearance is varied, depending on the stage of development of the lesion. PVL is resistant to most kinds of therapy; therefore, the control of this disease is difficult, especially in the late course of disease in which multiple lesions usually occur. The early diagnosis of this lesion is necessary. Thus, the clinicians should recognize and be familiar with the expression of this disease.



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