Giant cell fibroma of the oral cavity. II. An immunohistochemical study

Authors

Somporn Swasdison
Kittipong Dhanuthai

Publication Date

2000-09-01

Abstract

Objective The purpose of this study was to investigate the phenotype of the mononuclear and the multinucleated cells in the oral giant cell fibroma. Materials and methods The study was performed in thirty-one cases of the oral giant cell fibroma. The surgical specimens of the lesions were stained with a panel of antibodies using indirect immunoperoxidase technique. Results The mononuclear and multinucleated giant cells of the giant cell fibroma showed positive staining by antibodies against vimentin and proliferating cell nuclear antigen (PCNA) while demonstrating negative staining by antibodies against S-100 antigen, leukocyte common antigen (LCA), macrophage marker (LNS), smooth muscle actin (SMA) and cell cycle proliferation marker (Ki67). Conclusion The results suggested that the mononuclear and multinucleated giant cells of the giant cell fibroma were mesenchymal in origin and the multinucleated giant cells were probably derived from the fusion of differentiated mononuclear cells.

DOI

10.58837/CHULA.CUDJ.23.3.2

First Page

147

Last Page

152

Recommended Citation

Swasdison, Somporn and Dhanuthai, Kittipong (2000) "Giant cell fibroma of the oral cavity. II. An immunohistochemical study," Chulalongkorn University Dental Journal: Vol. 23: Iss. 3, Article 2.
DOI: 10.58837/CHULA.CUDJ.23.3.2
Available at: https://digital.car.chula.ac.th/cudj/vol23/iss3/2