Chulalongkorn University Dental Journal

Publication Date



Objective The purpose of this study was to investigate the phenotype of the mononuclear and the multinucleated cells in the oral giant cell fibroma. Materials and methods The study was performed in thirty-one cases of the oral giant cell fibroma. The surgical specimens of the lesions were stained with a panel of antibodies using indirect immunoperoxidase technique. Results The mononuclear and multinucleated giant cells of the giant cell fibroma showed positive staining by antibodies against vimentin and proliferating cell nuclear antigen (PCNA) while demonstrating negative staining by antibodies against S-100 antigen, leukocyte common antigen (LCA), macrophage marker (LNS), smooth muscle actin (SMA) and cell cycle proliferation marker (Ki67). Conclusion The results suggested that the mononuclear and multinucleated giant cells of the giant cell fibroma were mesenchymal in origin and the multinucleated giant cells were probably derived from the fusion of differentiated mononuclear cells.



First Page


Last Page


Included in

Dentistry Commons



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.