Chulalongkorn University Dental Journal

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Behçet's disease is a multisystemic inflammatory disease with histological evidence for vasculitis and characterized by mucocutaneous, ocular, articular, vascular, intestinal, pulmonary, renal and neurologic involvement. According to the diagnostic criteria formed by the International Study Group, recurrent oral ulceration is a prerequisite, with two more typical symptoms or signs. It is a disease of young adults with a more severe course in male subjects. Its prevalence is high in the Mediterranean basin, Turkey, Japan and those ethnic groups along the old Silk Route and has been known to be associated with HLA-B5 and HLA-B11. Although the pathogenesis of the disease is still unknown, most studies have proposed that immunologic factors may play a major role in its development in genetically predisposed individuals. It is well known that patients with Behçet's disease have an activated immune system, probably mediated by soluble factors in the circulation. The prognosis of the disease has been improved because of early diagnosis and suitable treatment. The management of Behçet's disease requires a multidisciplinary approach such as local, systemic and surgical therapies. Colchicine, corticosteroids, immunosuppressive drugs, and other agents have been applied for the appropiate treatment of Behçet's disease.



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